I’m kinda writing a guide (WIP) so here’s part of it.
**Method One: Porting Kit**
Warning: I am very unfamiliar with this and only heard of this about a month ago. Use at your own risk. First, download Porting Kit from http://portingkit.com/en/download.php. Download the Mac Core. Unzip and open Porting Kit, and click Library on the top of the window and click “Add Application” near the top of the window. Select the Mac Core. Now, click the Wineskin icon and click play to play the game. If you don’t trust Porting Kit or if this doesn’t work, try another method.
On to Wineskin.
**Method Two: Wineskin**
First, download Wineskin Winery from http://wineskin.urgesoftware.com/tiki-index.php?page=Downloads. Here’s where it starts to get fun 
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Again, we still need the Mac Core. In Finder, right-click the Core and click “Show Package Contents” then open “drive_c” then open “Program Files”. Copy the folder “Pokemon Insurgence 1.1.8.2 Mac” and paste it somewhere outside of the app, like Downloads or Desktop.
Now open Wineskin Winery. Make sure it says WS9Wine2.3 under “Installed Engines” and that is selected. If it isn’t highlighted, just click on it.
If WS9Wine2.3 is not listed, click the plus icon underneath the “Installed Engines” box. Select WS9Wine2.3 from the drop-down menu and click “Download and Install”, and you’re up to date!
Now, click “Create New Blank Wrapper”. Give whatever name you want, that’s gonna be the name of the application. Click “Cancel” when it asks to download Mono or Gecko, don’t worry about it. This might take a few minutes, so be patient. When it’s done, click “View Wrapper in Finder”.
Now, right-click the application you just made and open the “Wineskin” app. Click “Install Software” and select “Move a Folder” and find the folder you made earlier and choose that. It should ask which .exe file to run, and choose Game.exe (there’s only one, so if you don’t know what to do, just click “OK”. Now go back and open the application we created, and have fun playing!